Their paper 'Molecular structure of Nucleic Acids: A Structure for Deoxyribose Nucleic Acid' provided a brilliantly simple answer to the question of how genetic instructions were both stored inside organisms and passed from one generation to the next. It described Rosalind Franklin's discovery of the structure of DNA, and had a major impact on the field of biology, and genetics in particular.
Watson and Crick, along with Maurice Wilkins, were awarded the 1962 Nobel Prize in Physiology or Medicine "for their discoveries concerning the molecular structure of nucleic acids and its significance for information transfer in living material".
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